CoMFA and HQSAR Studies on 6,7-dimethoxy-4-pyrrolidylquinazoline Derivatives as Phosphodiesterase10A Inhibitors

Phosphodiesterase10A (PDE10A) is an important enzyme with diverse biological actions in intracellular signaling systems, making it an emerging target for diseases such as schizophrenia, Huntington’s disease, and diabetes mellitus. The objective of the current 3D QSAR study is to uncover some of the structural parameters which govern PDE10A inhibitory activity over PDE3A/B.



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